Glymphatic transport is reduced in rats with spontaneous pituitary tumor

Background and objective Pituitary tumor in patients induces adverse alterations the brain, accompanied by cognitive deficits. Dysfunction of glymphatic waste clearance results accumulation neurotoxic products within leading to impairment. However, status function brain with pituitary is unknown. Using magnetic resonance imaging (MRI) an advanced mathematical modeling, we investigated changes transport rats carrying spontaneous tumor. Methods Rats (22–24 months, female, Wistar) without ( n = 7/per group) underwent identical experimental protocol. MRI measurements, including T2-weighted dynamic 3D T1-weighted intracisternal administration contrast agent, were performed on each animal. The contrast-induced enhancement circle Willis influx nodes observed images verified time-signal-curves (TSCs). Model-derived parameters infusion rate that characterize kinetics tracer evaluated multiple representative regions. Results Our data demonstrated a higher incidence partially enhanced (86 vs. 14%; p < 0.033) lower (71 100%) pineal (57 86%) recesses than normal appearance gland, indicating intensification impaired peri-vascular pathway impeded due presence Consistently, our kinetic modeling regional cerebral tissue quantification revealed significantly rates all examined regions non-tumor rats, representing suppressed Conclusion study demonstrates compromised rat reduced efficiency increases risk for neurodegeneration may underlie impairment commonly seen tumors.